NeuroHTz

In their own words

NeuroHTz is a proposed neurotechnology-based screening system designed to explore early functional changes in brain activity associated with neurodegenerative disorders such as Alzheimer’s disease. The project is based on emerging neuroscience evidence that early cognitive decline and Mild Cognitive Impairment are linked to disruptions in Gamma Oscillations, which play a critical role in attention, memory processing, and communication between different brain regions. Gamma rhythms, particularly around 40 Hz, are thought to coordinate neural networks involved in higher cognitive functions such as working memory, sensory integration, and information processing. Studies have shown that in the early stages of Alzheimer’s, these neural oscillations become less synchronised and less responsive to external stimulation. NeuroHTz aims to investigate whether measuring the brain’s response to controlled 40 Hz auditory stimulation can provide insight into early neural network dysfunction before severe cognitive symptoms appear.The core concept of NeuroHTz involves combining three components: gamma-frequency auditory stimulation, electroencephalography (EEG) monitoring, and gamified cognitive assessment. During the experiment, participants are exposed to carefully designed 40 Hz auditory stimuli delivered through headphones, which are intended to entrain or synchronise neural activity in the gamma frequency band. While this stimulation is applied, EEG sensors record the brain’s electrical activity to measure neural responses such as gamma power, phase synchronization, and connectivity between different brain regions. These neural indicators reflect how effectively the brain can synchronize with the external rhythmic stimulus. Healthy individuals typically show strong gamma entrainment, while individuals experiencing early cognitive decline may demonstrate weaker or unstable neural synchronisation. In addition to neural monitoring, NeuroHTz incorporates a set of interactive, gamified cognitive tasks that evaluate attention, working memory, and reaction speed. These tasks provide behavioural measures of cognitive performance before and after stimulation, allowing researchers to examine whether gamma entrainment influences cognitive efficiency.By integrating neural signals and behavioural data, NeuroHTz creates a multidimensional framework for assessing brain function. Unlike traditional diagnostic methods that rely primarily on structural brain imaging or invasive biomarker testing, this approach focuses on functional brain network dynamics, which may change earlier in the disease process. The system is designed to be non-invasive, relatively low-cost, and potentially scalable, using portable EEG devices and digital cognitive testing interfaces. Such characteristics make it suitable for research settings and potentially for future screening applications in clinical or community environments. In the long term, data collected through NeuroHTz could be analysed using computational models and machine learning techniques to identify patterns associated with early neural dysfunction. These insights could contribute to the development of accessible screening strategies for neurodegenerative diseases and improve our understanding of how gamma-frequency neural activity relates to cognitive health.

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